Fludarabine-based reduced-intensity conditioning regimen for hematopoietic stem cell transplantation in pediatric patient with IL10 receptor deficiency

被引：0

作者：

Kheder, Maged ^{[1
,2
]}

Behfar, Maryam ^{[1
]}

Farajifard, Hamid ^{[1
,3
]}

Ali, Tahani ^{[1
,2
]}

Abou Fakher, Faihaa Hkima ^{[1
,2
]}

Hamidieh, Amir Ali ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Pediat Cell Therapy Res Ctr, Tehran, Iran

[2] Damascus Univ, Childrens Hosp, Pediat Stem Cell Transplant Dept, Damascus, Syria

[3] Qom Univ Med Sci & Hlth Serv, Immunol Microbiol Dept, Qom, Iran

来源：

PEDIATRIC TRANSPLANTATION | 2021年 / 25卷 / 02期

关键词：

hematopoietic stem cell transplantation; IL-10R deficiency; reduced-intensity conditioning; INFLAMMATORY-BOWEL-DISEASE;

D O I：

10.1111/petr.13819

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

IL-10R deficiency results in severe immune dysregulation. Herein, we describe the successful treatment of a girl aged 6.8 years with IL10R deficiency by using RIC prior to HSCT from a matched unrelated donor. The regimen was well tolerated, the engraftment was completely attained. On a follow-up of 7 months, the patient remained in good medical conditions with full donor chimerism. All complications before HSCT were completely resolved and her growth was accelerated. RIC regimen might be adequate to induce permanent engraftment and avoid severe organ toxicity in IL-10R deficiency patients.

引用

页数：3

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