Chemical constituents of Clathria reinwardti

被引：2

作者：

Do Thi Trang ^{[1
]}

Dan Thi Thuy Hang ^{[1
]}

Duong Thi Dung ^{[1
]}

Ngo Anh Bang ^{[1
]}

Phan Thi Thanh Huong ^{[1
]}

Pham Hai Yen ^{[1
,2
]}

Bui Huu Tai ^{[1
,2
]}

Nguyen Thi Cuc ^{[1
]}

Do Hoai An ^{[3
]}

Nguyen Xuan Nhiem ^{[1
,2
]}

Do Cong Thung ^{[4
]}

Phan Van Kiem ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi 10000, Vietnam

[2] VAST, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi 10000, Vietnam

[3] Hanoi Amsterdam Highsch Gifted, Hanoi 10000, Vietnam

[4] Vietnam Acad Sci & Technol, Inst Marine Environm & Resources, 246 Da Nang, Ngo Quyen 18000, Hai Phong, Vietnam

来源：

VIETNAM JOURNAL OF CHEMISTRY | 2022年 / 60卷 / S1期

关键词：

Demospongiae; Clathria reinwardti; sponge; diterpene; cytotoxic activity; AUSTRALIAN MARINE SPONGE; SOFT CORAL; METABOLITES; ALKALOIDS;

D O I：

10.1002/vjch.202200053

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Seven compounds, dihydrosinularin (1), 11-epi-sinulariolide acetate (2), 10,18-diacetoxydilabella-2,7-dien-6-one (3), 4-(2 ',3 ',4 '-trimethylphenyl)-but-(3E)-en-2-one (4), 4-hydroxybenzaldehyde (5), indole-3-aldehyde (6), and methyl indole-3-carboxylate (7) were isolated from Clathria reinwardti. The isolates were identified by ESIMS, 1D and 2D NMR spectra. Compounds 1-4 significantly exhibited the cytotoxic activity against SK-LU-1, MCF-7, HepG2, and SK-Mel-2 cell lines with the IC50 values ranging from 3.8 +/- 0.1 to 23.0 +/- 0.2 mu M, compared to the positive control compound (ellipticine, IC50, ranging from 1.4 +/- 0.2 to 1.7 +/- 0.1 mu M). This is the first report of these compounds from C. reinwardti.

引用

页码：21 / 26

页数：6

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