The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy

被引：3

作者：

Wang, Bo ^{[1
]}

Wang, Liping ^{[2
]}

Peng, Ying ^{[2
]}

Pang, Yiying ^{[2
]}

Xiao, Hesheng ^{[2
]}

Wang, Xiaoji ^{[2
]}

Huang, Shuangping ^{[3
,4
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Chem & Chem Engn, Nanchang 330013, Jiangxi, Peoples R China

[2] Jiangxi Sci & Technol Normal Univ, Sch Life Sci, Nanchang 330013, Jiangxi, Peoples R China

[3] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

[4] Taiyuan Univ Technol, Coll Biomed Engn, Taiyuan 030024, Shanxi, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 05期

基金：

美国国家科学基金会;

关键词：

methyl salvianolate A; Danshen; total synthesis; Horner-Wadsworth-Emmons reaction; silyl protecting group; SELECTIVE DEPROTECTION; ACID-A;

D O I：

10.3390/molecules24050999

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein, a convergent, practicable and first total synthesis of the natural product, (+/-)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner-Wadsworth-Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (+/-)-methyl salvianolate A and its derivatives on a reasonably large scale.

引用

页数：11

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