共 50 条
Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system
被引:15
作者:
Amiri, Shayan
[1
,2
,3
]
Haj-Mirzaian, Arya
[1
,2
]
Amini-Khoei, Hossein
[1
,2
]
Shirzadian, Armin
[1
,2
]
Rahimi-Balaei, Maryam
[4
]
Razmi, Ali
[5
]
Bergen, Hugo
[4
]
Rastegar, Mojgan
[3
]
Kordjazy, Nastaran
[1
,2
]
Haj-Mirzaian, Arvin
[1
]
Ejtemai-Mehr, Shahram
[1
,2
]
Dehpour, Ahmad Reza
[1
,2
]
机构:
[1] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, POB 13145-784, Tehran, Iran
[3] Univ Manitoba, Regenerat Med Program, Dept Biochem & Med Genet, Coll Med,Fac Hlth Sci, Winnipeg, MB, Canada
[4] Univ Manitoba, Dept Human Anat & Cell Sci, Coll Med, Fac Hlth Sci, Winnipeg, MB, Canada
[5] ACECR, Inst Med Plants, Med Plants Res Ctr, Karaj, Iran
关键词:
Social isolation stress;
Adolescence;
Lithium;
Nitrergic system;
Seizure;
NITRIC-OXIDE SYNTHASE;
FORCED SWIMMING TEST;
NEUROPSYCHIATRIC DISORDERS;
GLUCOCORTICOID-RECEPTOR;
ANIMAL-MODELS;
MALE-MICE;
SEIZURE;
HIPPOCAMPAL;
BEHAVIOR;
BRAIN;
D O I:
10.1016/j.yebeh.2016.04.035
中图分类号:
B84 [心理学];
C [社会科学总论];
Q98 [人类学];
学科分类号:
03 ;
0303 ;
030303 ;
04 ;
0402 ;
摘要:
In this study, we tested whether acute administration of lithium mitigates the deleterious effect of adolescent social isolation stress (SIS) on seizure susceptibility. In comparison with socially conditioned (SC) mice, isolated conditioned (IC) mice exhibited an increase in seizure susceptibility to pentylenetetrazole. Acute administration of lithium (10 mg/kg) reversed the proconvulsant effect of SIS in IC mice, but this effect was not observed in SC mice. Coadministration of subthreshold doses of lithium (3 mg/kg) with nitric oxide synthase (NOS) inhibitors reversed the effect of SIS on seizure susceptibility and decreased hippocampal nitrite levels in IC animals. In addition, a subthreshold dose of a nitric oxide precursor reduced the protective effect of lithium on seizure susceptibility and increased nitrite levels in the hippocampus of IC mice. These results suggest that lithium exerts a protective influence against the proconvulsant effect of adolescent SIS via a nitrergic system that includes activation of neuronal NOS in the hippocampus. (C) 2016 Elsevier Inc. All rights reserved.
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页码:6 / 13
页数:8
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