Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis

被引：5
作者：
Carpenter, KJ
Buckland, KF
Xing, Z
Hogaboam, CM
机构：
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[2] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada
来源：
INFECTION AND IMMUNITY | 2005年 / 73卷 / 12期
关键词：
D O I：
10.1128/IAI.73.12.8402-8406.2005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.
引用
收藏
页码：8402 / 8406
页数：5
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共 38 条
[11]   Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus [J].
Bozza, S ;
Gaziano, R ;
Spreca, A ;
Bacci, A ;
Montagnoli, C ;
di Francesco, P ;
Romani, L .
JOURNAL OF IMMUNOLOGY, 2002, 168 (03) :1362-1371
[12]   Menacing mold:: The molecular biology of Aspergillus fumigatus [J].
Brakhage, AA ;
Langfelder, K .
ANNUAL REVIEW OF MICROBIOLOGY, 2002, 56 :433-455
[13]   Time-varying risk and return in the bond market: A test of a new equilibrium pricing model [J].
Campbell, CJ ;
Kazemi, HB ;
Nanisetty, P .
REVIEW OF FINANCIAL STUDIES, 1999, 12 (03) :631-642
[14]   TREM-1 (triggering receptor expressed on myeloid cells): A new player in acute inflammatory responses [J].
Colonna, M ;
Facchetti, F .
JOURNAL OF INFECTIOUS DISEASES, 2003, 187 :S397-S401
[15]   Trems in the immune system and beyond [J].
Colonna, M .
NATURE REVIEWS IMMUNOLOGY, 2003, 3 (06) :445-453
[16]   Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia [J].
Gibot, S ;
Cravoisy, A ;
Levy, B ;
Bene, MC ;
Faure, G ;
Bollaert, PE .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (05) :451-458
[17]   Plasma level of a triggering receptor expressed on myeloid cells-1:: Its diagnostic accuracy in patients with suspected sepsis [J].
Gibot, S ;
Kolopp-Sarda, MN ;
Béné, MC ;
Cravoisy, A ;
Levy, B ;
Faure, GC ;
Bollaert, PE .
ANNALS OF INTERNAL MEDICINE, 2004, 141 (01) :9-15
[18]   Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309 [J].
Inngjerdingen, M ;
Damaj, B ;
Maghazachi, AA .
JOURNAL OF IMMUNOLOGY, 2000, 164 (08) :4048-4054
[19]   Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice [J].
Jakubzick, C ;
Wen, HT ;
Matsukawa, A ;
Keller, M ;
Kunkel, SL ;
Hogaboam, CM .
AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (04) :1211-1221
[20]   CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages [J].
Katakura, T ;
Miyazaki, M ;
Kobayashi, M ;
Herndon, DN ;
Suzuki, F .
JOURNAL OF IMMUNOLOGY, 2004, 172 (03) :1407-1413
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