Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis

被引：5
作者：
Carpenter, KJ
Buckland, KF
Xing, Z
Hogaboam, CM
机构：
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[2] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada
来源：
INFECTION AND IMMUNITY | 2005年 / 73卷 / 12期
关键词：
D O I：
10.1128/IAI.73.12.8402-8406.2005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.
引用
收藏
页码：8402 / 8406
页数：5
相关论文
共 38 条
[1]   The role of the DAP12 signal in mouse myeloid differentiation [J].
Aoki, N ;
Kimura, S ;
Takiyama, Y ;
Atsuta, Y ;
Abe, A ;
Sato, K ;
Katagiri, M .
JOURNAL OF IMMUNOLOGY, 2000, 165 (07) :3790-3796
[2]   Role of DAP12 in innate and adaptive immune responses [J].
Aoki, N ;
Kimura, S ;
Xing, Z .
CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (01) :7-10
[3]   Differential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection [J].
Aoki, N ;
Zganiacz, A ;
Margetts, P ;
Xing, Z .
INFECTION AND IMMUNITY, 2004, 72 (05) :2477-2483
[4]   DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming [J].
Bakker, ABH ;
Hoek, RM ;
Cerwenka, A ;
Blom, B ;
Lucian, L ;
McNeil, T ;
Murray, R ;
Phillips, JH ;
Sedgwick, JD ;
Lanier, LL .
IMMUNITY, 2000, 13 (03) :345-353
[5]   A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response [J].
Bleharski, JR ;
Kiessler, V ;
Buonsanti, C ;
Sieling, PA ;
Stenger, S ;
Colonna, M ;
Modlin, RL .
JOURNAL OF IMMUNOLOGY, 2003, 170 (07) :3812-3818
[6]   A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells [J].
Bouchon, A ;
Hernández-Munain, C ;
Cella, M ;
Colonna, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (08) :1111-1122
[7]   Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes [J].
Bouchon, A ;
Dietrich, J ;
Colonna, M .
JOURNAL OF IMMUNOLOGY, 2000, 164 (10) :4991-4995
[8]   TREM-1 amplifies inflammation and is a crucial mediator of septic shock [J].
Bouchon, A ;
Facchetti, F ;
Weigand, MA ;
Colonna, M .
NATURE, 2001, 410 (6832) :1103-1107
[9]   A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation [J].
Bozza, S ;
Perruccio, K ;
Montagnoli, C ;
Gaziano, R ;
Bellocchio, S ;
Burchielli, E ;
Nkwanyuo, G ;
Pitzurra, L ;
Velardi, A ;
Romani, L .
BLOOD, 2003, 102 (10) :3807-3814
[10]   Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants [J].
Bozza, S ;
Gaziano, R ;
Lipford, GB ;
Montagnoli, C ;
Bacci, A ;
Di Francesco, P ;
Kurup, VP ;
Wagner, H ;
Romani, L .
MICROBES AND INFECTION, 2002, 4 (13) :1281-1290
1234