Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives

被引：39
作者：
Kim, Dong. Hee [1 ,2 ]
Gim, Jeong-An [1 ,3 ]
Yeo, Seung Hyeon [4 ]
Kim, Heui-Soo [1 ,3 ]
机构：
[1] Pusan Natl Univ, Coll Nat Sci, Dept Biol Sci, Busan 46241, South Korea
[2] Hyungju Hosp, Dept Psychiat, Yangsan Si, Gyeongsangnam D, South Korea
[3] Pusan Natl Univ, Genet Engn Inst, Busan 46241, South Korea
[4] Gyeongsangnam Prov Yangsan Hosp Elderly, Dept Neurol, Yangsan Si, Gyeongsangnam D, South Korea
来源：
GENE | 2017年 / 597卷
关键词：
Alzheimer's disease; GWAS; LOAD; cholesterol metabolism; brain; GENOME-WIDE ASSOCIATION; CENTRAL-NERVOUS-SYSTEM; AMYLOID-BETA-PEPTIDE; APOE EPSILON-4 ALLELE; BLOOD-BRAIN-BARRIER; APOLIPOPROTEIN-E; RISK-FACTORS; IDENTIFIES VARIANTS; PLASMA CLUSTERIN; COMMON VARIANTS;
D O I：
10.1016/j.gene.2016.10.022
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Late onset Alzheimer's disease (LOAD) is the most common type of dementia and is characterized by decreased amyloid-beta (A beta) clearance from the brain. Cholesterol regulates the production and clearance of A beta. Genome-wide association study (GWAS) suggests that at least 20 genes are associated with LOAD. The genes APOE, CLU, SORL1, PICALM, and BIN1 have a relatively high LOAD susceptibility. Additional experimental and bioinformatic approaches to integrate data from genetics, epigenetics, and molecular networks may further increase our understanding of LOAD in relation to cholesterol metabolism and trafficking. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：10 / 16
页数：7
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