Host Gene Expression Changes Correlating With Anti-HIV-1 Effects in Human Subjects After Treatment With Peginterferon Alfa-2a

被引：17

作者：

Hubbard, Jonathan J. ^{[1
]}

Greenwell-Wild, Teresa ^{[2
]}

Barrett, Lisa ^{[1
]}

Yang, Jun ^{[3
]}

Lempicki, Richard A. ^{[3
]}

Wahl, Sharon M. ^{[2
]}

Asmuth, David M. ^{[4
]}

Murphy, Robert L. ^{[5
]}

Pollard, Richard B. ^{[4
]}

Kottilil, Shyam ^{[1
]}

机构：

[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD USA

[3] SAIC Frederick Inc, Frederick, MD USA

[4] Univ Calif Davis, Med Ctr, Sacramento, CA 95817 USA

[5] Northwestern Univ, Evanston, IL USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2012年 / 205卷 / 09期

基金：

美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONIC HEPATITIS-C; PEGYLATED INTERFERON; RIBAVIRIN; REPLICATION; TRIAL; BETA;

D O I：

10.1093/infdis/jis211

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r = 5 20.7; P < .05) with virological response. The strength of peginterferon alfa-2-ainduced IFIG response significantly correlated with declines in HIV load during treatment (r(2) = 0.87, p = .003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.

引用

页码：1443 / 1447

页数：5