Concise Review: Forkhead Pathway in the Control of Adult Neurogenesis

被引：43

作者：

Genin, Emmanuelle C. ^{[1
]}

Caron, Nicolas ^{[1
]}

Vandenbosch, Renaud ^{[1
]}

Laurent Nguyen ^{[1
]}

Malgrange, Brigitte ^{[1
]}

机构：

[1] Univ Liege, GIGA Neurosci, Dev Neurobiol Unit, B-4000 Liege, Belgium

来源：

STEM CELLS | 2014年 / 32卷 / 06期

关键词：

Neural stem cell; Neural differentiation; Proliferation; Progenitor cells; Transcription factors; NEURAL STEM-CELLS; FOXO TRANSCRIPTION FACTORS; GENE-EXPRESSION; PROMOTES TUMORIGENESIS; EPENDYMAL CELLS; SELF-RENEWAL; PROTEIN; CILIA; PHOSPHORYLATION; BINDING;

D O I：

10.1002/stem.1673

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

New cells are continuously generated from immature proliferating cells in the adult brain in two neurogenic niches known as the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus and the sub-ventricular zone (SVZ) of the lateral ventricles. However, the molecular mechanisms regulating their proliferation, differentiation, migration and functional integration of newborn neurons in pre-existing neural network remain largely unknown. Forkhead box (Fox) proteins belong to a large family of transcription factors implicated in a wide variety of biological processes. Recently, there has been accumulating evidence that several members of this family of proteins play important roles in adult neurogenesis. Here, we describe recent advances in our understanding of regulation provided by Fox factors in adult neurogenesis, and evaluate the potential role of Fox proteins as targets for therapeutic intervention in neurodegenerative diseases.

引用

页码：1398 / 1407

页数：10

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