Understanding the link between insulin resistance and Alzheimer's disease: Insights from animal models

被引：30

作者：

Lyra e Silva, Natalia de M. ^{[1
]}

Goncalves, Rafaella Araujo ^{[1
]}

Boehnke, Susan E. ^{[1
]}

Forny-Germano, Leticia ^{[3
]}

Munoz, Douglas P. ^{[1
]}

De Felice, Fernanda G. ^{[1
,2
,3
]}

机构：

[1] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada

[2] Queens Univ, Dept Psychiat, Kingston, ON, Canada

[3] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo De Meis, Rio De Janeiro, Brazil

来源：

EXPERIMENTAL NEUROLOGY | 2019年 / 316卷

基金：

加拿大健康研究院;

关键词：

Alzheimer's disease; Insulin; Insulin resistance; Cognitive control; Inflammation; Animal models; ENDOPLASMIC-RETICULUM STRESS; REDUCES FOOD-INTAKE; DEPENDENT SYNAPSE FORMATION; UNFOLDED PROTEIN RESPONSE; BETA-AMYLOID OLIGOMERS; LONG-TERM POTENTIATION; 3XTG-AD MOUSE MODEL; BRAIN INSULIN; A-BETA; RAT-BRAIN;

D O I：

10.1016/j.expneurol.2019.03.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is a devastating neurodegenerative disease affecting millions of people worldwide. AD is characterized by a profound impairment of higher cognitive functions and still lacks any effective disease-modifying treatment. Defective insulin signaling has been implicated in AD pathophysiology, but the mechanisms underlying this process are not fully understood. Here, we review the molecular mechanisms underlying defective brain insulin signaling in rodent models of AD, and in a non-human primate (NHP) model of the disease that recapitulates features observed in AD brains. We further highlight similarities between the NHP and human brains and discuss why NHP models of AD are important to understand disease mechanisms and to improve the translation of effective therapies to humans. We discuss how studies using different animal models have contributed to elucidate the link between insulin resistance and AD.

引用

页码：1 / 11

页数：11

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