A study on the reproductive toxicity of erythrosine in male mice

被引:37
作者
Aziz, AHA
Shouman, SA
Attia, AS
Saad, SF
机构
[1] CAIRO UNIV, DEPT PHARMACOL & TOXICOL, CAIRO, EGYPT
[2] CAIRO UNIV, NATL CANC INST, DEPT CANC BIOL, CAIRO, EGYPT
关键词
erythrosine; spermatogenesis; reproduction; colouring agents;
D O I
10.1006/phrs.1997.0158
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Worldwide usage of different colouring agents in the food industry prompted us to study their toxicity, The potential adverse effects of erythrosine (ER, FD & C Red No.3) on the spermatogenesis process were investigated in adult mice. Testicular lactic dehydrogenase isoenzyme activity (LDH-X), a pachytene spermatocyte marker of testicular toxicity, was significantly decreased to 71.8% and 68.6% of the control value after daily p,o. administration of ER (21 days) in doses of 68 and 136 mg kg(-1) respectively. At the same time, the normal average epididymal sperm count as well as the percentage of motile sperms were significantly inhibited by about 50% and 57% respectively. Moreover, ER was shown to disrupt the normal morphology of the sperm head. Thus, after 5 daily p,o administrations of ER in doses of 680 and 1360 mg kg(-1)(equivalent to 10 and 20% of its LD50) it increased the incidence of sperms with abnormal head by about 57% and 65% respectively. The induced increase in sperm abnormalities could enhance the spermatogenic dysfunction and germ cell mutagenicity. These findings indicate that ER in the used doses has a potential toxic effect on spermatogenesis in mice and in turn, it may affect its testicular function and reproductive performance. (C) 1997 The Italian Pharmacological Society.
引用
收藏
页码:457 / 462
页数:6
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