Backbone and side-chain chemical shift assignments of p50 subunit of NF-κB transcription factor

被引：2
作者：
Singh, Amrinder [1 ]
Dyson, H. Jane [1 ]
机构：
[1] Scripps Res, Dept Integrat Struct & Computat Biol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
来源：
BIOMOLECULAR NMR ASSIGNMENTS | 2021年 / 15卷 / 01期
基金：
美国国家卫生研究院;
关键词：
p50; DBD; NF-kappa B; Resonance assignments; Chemical shift;
D O I：
10.1007/s12104-020-09978-z
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Nuclear Factor kappa B (NF-kappa B) is a family of five related transcription factors that recognize a kappa B DNA element on the promoter and enhancer regions of target genes and modulate their expression. Here we report a complete set of(1)H,C-13,N-15 backbone and side chain resonance assignments for the p50 DNA binding and dimerization domains of the p50 homodimer form of the NF-kappa B transcription factor. The chemical shift data constitute a first step towards understanding the mechanism of interaction of the p50 homodimer with DNA.
引用
收藏
页码：29 / 33
页数：5
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