Anti-H5N1 virus new diglyceride ester from the Red Sea grass Thallasodendron ciliatum

被引：12

作者：

Ibrahim, Amany K. ^{[1
]}

Youssef, Ahmed I. ^{[2
]}

Arafa, Abdel Satar ^{[3
]}

Foad, Reda ^{[1
]}

Radwan, Mohamed M. ^{[4
]}

Ross, Samir ^{[4
,5
]}

Hassanean, Hashim A. ^{[1
]}

Ahmed, Safwat A. ^{[1
]}

机构：

[1] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt

[2] Suez Canal Univ, Div Zoonoses, Dept Hyg & Zoonoses, Fac Vet Med, Ismailia 41522, Egypt

[3] Anim Hlth Res Inst, Natl Lab Vet Qual Control Poultry Prod NLQP, Giza, Egypt

[4] Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, University, MS 38677 USA

[5] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 18期

关键词：

Thallasodendron ciliatum; diglyceride ester; asebotin; anti-influenza virus (H5N1); AVIAN INFLUENZA; ADAMANTANE RESISTANCE; GROWTH; ASSAY;

D O I：

10.1080/14786419.2012.742082

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Some Egyptian plants were screened against highly pathogenic avian influenza strain H5N1 using plaque inhibition assay in Madin-Darby canine kidney. The results indicated that the extracts of Red Sea grass Thallasodendron ciliatum possessed potent antiviral activity (100% inhibition at the concentration of 1gmL(-1)). The bioactivity-guided fractionations led to the isolation of a new diglyceride ester (1) along with asebotin (2) for the first time from the plant. The two isolates showed reduction of virus titre by 67.26% and 53.81% inhibition at concentration of 1ngmL(-1), respectively.

引用

页码：1625 / 1632

页数：8

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