Vitamin D and Sarcopenia: Potential of Vitamin D Supplementation in Sarcopenia Prevention and Treatment

被引：137

作者：

Uchitomi, Ran ^{[1
]}

Oyabu, Mamoru ^{[1
]}

Kamei, Yasutomi ^{[1
]}

机构：

[1] Kyoto Prefectural Univ, Grad Sch Life & Environm Sci, Kyoto 6068522, Japan

来源：

NUTRIENTS | 2020年 / 12卷 / 10期

关键词：

vitamin D; sarcopenia; atrophy; skeletal muscle; gene regulation; nuclear receptor; ASIAN WORKING GROUP; D-RECEPTOR GENE; SKELETAL-MUSCLE; 1,25-DIHYDROXYVITAMIN D-3; 25-HYDROXYVITAMIN D; D METABOLISM; EXPRESSION; STRENGTH; LIGAND; ACTIVATION;

D O I：

10.3390/nu12103189

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Skeletal muscle, the largest organ in the human body, accounting for approximately 40% of body weight, plays important roles in exercise and energy expenditure. In the elderly, there is often a progressive decline in skeletal muscle mass and function, a condition known as sarcopenia, which can lead to bedridden conditions, wheelchair confinement as well as reducing the quality of life (QOL). In developed countries with aging populations, the prevention and management of sarcopenia are important for the improvement of health and life expectancy in these populations. Recently, vitamin D, a fat-soluble vitamin, has been attracting attention due to its importance in sarcopenia. This review will focus on the effects of vitamin D deficiency and supplementation on sarcopenia.

引用

页码：1 / 12

页数：12

共 72 条

[1] Stabilization of Vitamin D in Pea Protein Isolate Nanoemulsions Increases Its Bioefficacy in Rats [J].

Almajwal, Ali M. ;

Abulmeaty, Mahmoud M. A. ;

Feng, Hao ;

Alruwaili, Nawaf W. ;

Dominguez-Uscanga, Astrid ;

Andrade, Juan E. ;

Razak, Suhail ;

ElSadek, Mohamed F. .

NUTRIENTS, 2019, 11 (01)

[2] Vitamin D Status in Japanese Adults: Relationship of Serum 25-Hydroxyvitamin D with Simultaneously Measured Dietary Vitamin D Intake and Ultraviolet Ray Exposure [J].

Asakura, Keiko ;

Etoh, Norihito ;

Imamura, Haruhiko ;

Michikawa, Takehiro ;

Nakamura, Takahiro ;

Takeda, Yuki ;

Mori, Sachie ;

Nishiwaki, Yuji .

NUTRIENTS, 2020, 12 (03)

[3] Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP [J].

Asano, Lisa ;

Watanabe, Mizuki ;

Ryoden, Yuta ;

Usuda, Kousuke ;

Yamaguchi, Takuya ;

Khambu, Bilon ;

Takashima, Megumi ;

Sato, Shin-ichi ;

Sakai, Juro ;

Nagasawa, Kazuo ;

Uesugi, Motonari .

CELL CHEMICAL BIOLOGY, 2017, 24 (02) :207-217

[4] The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts [J].

Ashcroft, Stephen P. ;

Bass, Joseph J. ;

Kazi, Abid A. ;

Atherton, Philip J. ;

Philp, Andrew .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2020, 318 (03) :C536-C541

[5] Overexpression of the vitamin D receptor (VIM) induces skeletal muscle hypertrophy [J].

Bass, Joseph J. ;

Nakhuda, Asif ;

Deane, Colleen S. ;

Brook, Matthew S. ;

Wilkinson, Daniel J. ;

Phillips, Bethan E. ;

Philp, Andrew ;

Tarum, Janelle ;

Kadi, Fawzi ;

Andersen, Ditte ;

Garcia, Amadeo Munoz ;

Smith, Ken ;

Gallagher, Iain J. ;

Szewczyk, Nathaniel J. ;

Cleasby, Mark E. ;

Atherton, Philip J. .

MOLECULAR METABOLISM, 2020, 42

[6] The Effects of Vitamin D on Skeletal Muscle Strength, Muscle Mass, and Muscle Power: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [J].

Beaudart, Charlotte ;

Buckinx, Fanny ;

Rabenda, Veronique ;

Gillain, Sophie ;

Cavalier, Etienne ;

Slomian, Justine ;

Petermans, Jean ;

Reginster, Jean-Yves ;

Bruyere, Olivier .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (11) :4336-4345

[7] Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials [J].

Bischoff-Ferrari, H. A. ;

Dawson-Hughes, B. ;

Staehelin, H. B. ;

Orav, J. E. ;

Stuck, A. E. ;

Theiler, R. ;

Wong, J. B. ;

Egli, A. ;

Kiel, D. P. ;

Henschkowski, J. .

BMJ-BRITISH MEDICAL JOURNAL, 2009, 339 :843

[8] 2 NUCLEAR SIGNALING PATHWAYS FOR VITAMIN-D [J].

CARLBERG, C ;

BENDIK, I ;

WYSS, A ;

MEIER, E ;

STURZENBECKER, LJ ;

GRIPPO, JF ;

HUNZIKER, W .

NATURE, 1993, 361 (6413) :657-660

[9] A Randomized Study on the Effect of Vitamin D3 Supplementation on Skeletal Muscle Morphology and Vitamin D Receptor Concentration in Older Women [J].

Ceglia, Lisa ;

Niramitmahapanya, Sathit ;

Morais, Mauricio da Silva ;

Rivas, Donato A. ;

Harris, Susan S. ;

Bischoff-Ferrari, Heike ;

Fielding, Roger A. ;

Dawson-Hughes, Bess .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (12) :E1927-E1935

[10] Vitamin D and Its Role in Skeletal Muscle [J].

Ceglia, Lisa ;

Harris, Susan S. .

CALCIFIED TISSUE INTERNATIONAL, 2013, 92 (02) :151-162

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