Effect of Muramyl Dipeptides on Postsynaptic GABA, NMDA, and AMPA Receptors and Presynaptic NMDA Receptors in Rat Brain

被引：1
|
作者：
Grigoriev, V. V. [1 ]
Petrova, L. N. [1 ]
Gabreliyan, A. V. [1 ]
Ivanova, T. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Physiol Act Subst, Lab Neurochem Physiol Act Subst, Chernogolovka, Moscow Region, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 146卷 / 03期
关键词：
muramyl dipeptides; receptors; synaptosomes; calcium;
D O I：
10.1007/s10517-008-0283-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors. L,D-Dipeptide more potently than L,L-dipeptide inhibited postsynaptic NMDA receptors, potentiated GABA and AMPA receptors, and inhibited Ca-45(2+) uptake in synaptosomes from of rat brain cortex. Our results indicate that muramyl dipeptides modulate function of glutamate and GABA receptors.
引用
收藏
页码：276 / 278
页数：3
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