The feasibility of improving discourse in people with aphasia through AAC: clinical and functional MRI correlates

被引:24
作者
Dietz, Aimee [1 ]
Vannest, Jennifer [2 ]
Maloney, Thomas [2 ]
Altaye, Mekibib [2 ]
Holland, Scott [2 ]
Szaflarski, Jerzy P. [3 ]
机构
[1] Univ Cincinnati, Dept Commun Sci & Disorders, 3202 Eden Ave, Cincinnati, OH 45267 USA
[2] Cincinnati Childrens Hosp Med Ctr, Pediat Neuroimaging Res Consortium, Cincinnati, OH 45229 USA
[3] Univ Alabama Birmingham, Dept Neurol, UAB Stn, Birmingham, AL 35294 USA
基金
美国国家卫生研究院;
关键词
Aphasia; augmentative and alternative communication; fMRI; cortical plasticity; neuroimaging; POSTSTROKE APHASIA; LANGUAGE NETWORKS; CONNECTED SPEECH; VERB RETRIEVAL; RECOVERY; IMPACT; THERAPY; GESTURE; ANOMIA; FMRI;
D O I
10.1080/02687038.2018.1447641
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Background:The theory of intersystemic reorganization, along with the ability of people with chronic aphasia to recover language function, suggests that a high-tech augmentative and alternative communication (AAC) device could be employed as a dual-purpose tool that simultaneously facilitates language recovery and compensates for deficits. To date, treatments based on intersystemic reorganization have focused on writing, drawing, and gesturing. Further, despite a movement to identify neural mechanisms that support intervention-related recovery, the neurobiological markers of AAC-induced changes have not been established.Aims: The purpose of this study is twofold: (1) to examine the feasibility of providing a high-tech AAC treatment to people with chronic aphasia, with the goal of evoking changes in spoken language; and (2) to identify evidence of AAC-induced changes in brain activation.Method and Procedures: We employed a pre- and post-treatment design with a control (usual care) group to observe the impact of an AAC treatment on aphasia severity and spoken discourse. Further, we used functional magnetic resonance imaging (fMRI) to examine associated neural reorganization.Outcomes and Results: Compared to the usual care group, the AAC intervention trended toward larger treatment effects and resulted in a higher number of responders on behavioral outcomes. Both groups demonstrated a trend toward greater leftward lateralization of language functions via fMRI. Secondary analyses of responders to treatment revealed increased activation in visual processing regions, primarily for the AAC group.Conclusions: This study provides preliminary guidance regarding how to implement AAC treatment in a manner that simultaneously facilitates language recovery across a variety of aphasia types and severity levels while compensating for residual deficits in people with chronic aphasia. Further, this work motivates continued efforts to unveil the role of AAC-based interventions in the aphasia recovery process and provides insight regarding the neurobiological mechanisms supporting AAC-induced language changes.
引用
收藏
页码:693 / 719
页数:27
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