Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

被引：47

作者：

Anaeigoudari, Akbar ^{[1
]}

Shafei, Mohammad Naser ^{[1
]}

Soukhtanloo, Mohammad ^{[2
]}

Sadeghnia, Hamid Reza ^{[3
]}

Reisi, Parham ^{[4
]}

Beheshti, Farimah ^{[1
]}

Mohebbati, Reza ^{[5
]}

Mousavi, Seyed Mojtaba ^{[5
]}

Hosseini, Mahmoud ^{[5
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Neurocognit Res Ctr, Mashhad 9177948564, Iran

[2] Mashhad Univ Med Sci, Sch Med, Dept Biochem, Mashhad 9177948564, Iran

[3] Mashhad Univ Med Sci, Sch Med, Pharmacol Res Ctr Med Plants, Mashhad 9177948564, Iran

[4] Isfahan Univ Med Sci, Sch Med, Dept Physiol, Esfahan, Iran

[5] Mashhad Univ Med Sci, Sch Med, Neurogen Inflammat Res Ctr, Mashhad 9177948564, Iran

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2015年 / 73卷 / 09期

关键词：

learning; memory; lipopolysaccharide; 7NI; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; OVARIECTOMIZED RATS; ALZHEIMERS-DISEASE; BRAIN; HIPPOCAMPUS; MICE; INFLAMMATION; SCOPOLAMINE; DYSFUNCTION;

D O I：

10.1590/0004-282X20150121

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI.

引用

页码：784 / 790

页数：7

共 34 条

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