Synthesis, bioactivity and DFT structure-activity relationship study of novel 1,2,3-thiadiazole derivatives

被引：64

作者：

Liu, Xing-Hai ^{[1
]}

Zhao, Wei-Guang ^{[2
]}

Wang, Bao-Lei ^{[2
]}

Li, Zheng-Ming ^{[2
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China

[2] Nankai Univ, Natl Pesticidal Engn Ctr, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2012年 / 38卷 / 08期

基金：

中国国家自然科学基金;

关键词：

1,2,3-Thiadiazole; Synthesis; KARI activity; Herbicidal activity; DFT study; KETOL-ACID REDUCTOISOMERASE;

D O I：

10.1007/s11164-012-0521-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 1,2,3-thiadiazole derivatives were designed and synthesized. Their structures were characterized by H-1 NMR, MS and HRMS. The bioactivity tests indicated that compound 9b exhibits a favorable KARI inhibition rate, and some of these novel compounds also showed moderate herbicidal activity against Brassica campestris.

引用

页码：1999 / 2008

页数：10

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