Structural organization of the kinetochore-microtubule interface

被引：87

作者：

DeLuca, Jennifer G. ^{[1
]}

Musacchio, Andrea ^{[2
,3
]}

机构：

[1] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA

[2] Max Planck Inst Mol Physiol, Dept Mechanist Cell Biol, D-44227 Dortmund, Germany

[3] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

来源：

CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SPINDLE ASSEMBLY CHECKPOINT; MOLECULAR ARCHITECTURE; CENP-A; NDC80; COMPLEX; YEAST KINETOCHORE; ATTACHMENT SITE; CHROMOSOME SEGREGATION; PROTEIN ARCHITECTURE; OUTER KINETOCHORE; CELL-DIVISION;

D O I：

10.1016/j.ceb.2011.11.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Successful mitosis depends on the stable, yet regulated attachment of chromosomes to spindle microtubules. The kinetochore, a large macromolecular structure assembled at sites of centromeric heterochromatin, is responsible for generating and regulating these essential attachments. Over the last several years, concerted experimental efforts have brought the structural view of the kinetochore-microtubule interface more clearly into focus. Here, we review important recent advancements and discuss several unresolved questions regarding how kinetochores dynamically bridge mitotic chromosomes to spindle microtubules.

引用

页码：48 / 56

页数：9

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