Essential domains of phosphatidylinositol-4 kinase III β required for enterovirus replication

被引：7

作者：

Arita, Minetaro ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 2, 4-7-1 Gakuen, Musashimurayama, Tokyo 2080011, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2019年 / 63卷 / 07期

关键词：

ACBD3; enterovirus; PI4KB; picornavirus; RAB11; virus; RNA REPLICATION; PROTEIN ACBD3; 3A PROTEIN; BINDING; RECRUITMENT; PI4KB; PI4KIII-BETA; CHOLESTEROL; ORGANELLES; PATHWAY;

D O I：

10.1111/1348-0421.12718

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phosphatidylinositol-4 kinase III beta (PI4KB) is a host factor that is required for enterovirus (EV) replication. In this study, the importance of host proteins that interact with PI4KB in EV replication was analyzed by trans complementation with PI4KB mutants in a PI4KB-knockout cell line. Ectopically expressed PI4KB mutants, which lack binding regions for ACBD3, RAB11, and 14-3-3 proteins, rescued replication of poliovirus and enterovirus 71. These findings suggest that interaction of PI4KB with these host proteins is not essential for EV replication once PI4KB has been expressed and that PI4KB is functionally independent from these host proteins regarding EV replication.

引用

页码：285 / 288

页数：4

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