Essential domains of phosphatidylinositol-4 kinase III β required for enterovirus replication

被引：7
|
作者：
Arita, Minetaro [1 ]
机构：
[1] Natl Inst Infect Dis, Dept Virol 2, 4-7-1 Gakuen, Musashimurayama, Tokyo 2080011, Japan
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2019年 / 63卷 / 07期
关键词：
ACBD3; enterovirus; PI4KB; picornavirus; RAB11; virus; RNA REPLICATION; PROTEIN ACBD3; 3A PROTEIN; BINDING; RECRUITMENT; PI4KB; PI4KIII-BETA; CHOLESTEROL; ORGANELLES; PATHWAY;
D O I：
10.1111/1348-0421.12718
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Phosphatidylinositol-4 kinase III beta (PI4KB) is a host factor that is required for enterovirus (EV) replication. In this study, the importance of host proteins that interact with PI4KB in EV replication was analyzed by trans complementation with PI4KB mutants in a PI4KB-knockout cell line. Ectopically expressed PI4KB mutants, which lack binding regions for ACBD3, RAB11, and 14-3-3 proteins, rescued replication of poliovirus and enterovirus 71. These findings suggest that interaction of PI4KB with these host proteins is not essential for EV replication once PI4KB has been expressed and that PI4KB is functionally independent from these host proteins regarding EV replication.
引用
收藏
页码：285 / 288
页数：4
相关论文
共 50 条
  • [1] Mechanism of Poliovirus Resistance to Host Phosphatidylinositol-4 Kinase III β Inhibitor
    Arita, Minetaro
    ACS INFECTIOUS DISEASES, 2016, 2 (02): : 140 - 148
  • [2] Inhibition of protein kinase D and its substrate phosphatidylinositol-4 kinase III beta blocks common human coronavirus replication
    Han, Huijuan
    Liu, Huan
    Steiner, Rebbeca
    Zhao, Zhijun
    Jin, Zheng-Gen
    MICROBIOLOGY SPECTRUM, 2024, 12 (12)
  • [3] Enterovirus 3A Facilitates Viral Replication by Promoting Phosphatidylinositol 4-Kinase IIIβ-ACBD3 Interaction
    Xiao, Xia
    Lei, Xiaobo
    Zhang, Zhenzhen
    Ma, Yijie
    Qi, Jianli
    Wu, Chao
    Xiao, Yan
    Li, Li
    He, Bin
    Wang, Jianwei
    JOURNAL OF VIROLOGY, 2017, 91 (19)
  • [4] A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ
    van der Schaar, Hilde M.
    Leyssen, Pieter
    Thibaut, Hendrik J.
    de Palma, Armando
    van der Linden, Lonneke
    Lanke, Kjerstin H. W.
    Lacroix, Celine
    Verbeken, Erik
    Conrath, Katja
    MacLeod, Angus M.
    Mitchell, Dale R.
    Palmer, Nicholas J.
    de Pooel, Herve van
    Andrews, Martin
    Neyts, Johan
    van Kuppevelda, Frank J. M.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (10) : 4971 - 4981
  • [5] Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex
    Hausser, A
    Storz, P
    Märtens, S
    Link, G
    Toker, A
    Pfizenmaier, K
    NATURE CELL BIOLOGY, 2005, 7 (09) : 880 - U24
  • [6] Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex
    Angelika Hausser
    Peter Storz
    Susanne Märtens
    Gisela Link
    Alex Toker
    Klaus Pfizenmaier
    Nature Cell Biology, 2005, 7 : 880 - 886
  • [7] Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication
    Berger, Kristi L.
    Kelly, Sean M.
    Jordan, Tristan X.
    Tartell, Michael A.
    Randall, Glenn
    JOURNAL OF VIROLOGY, 2011, 85 (17) : 8870 - 8883
  • [8] Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III β to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation
    Jeganathan, Sujeeve
    Morrow, Anne
    Amiri, Anahita
    Lee, Jonathan M.
    MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (14) : 4549 - 4561
  • [9] The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A
    Reiss, Simon
    Harak, Christian
    Romero-Brey, Ines
    Radujkovic, Danijela
    Klein, Rahel
    Ruggieri, Alessia
    Rebhan, Ilka
    Bartenschlager, Ralf
    Lohmann, Volker
    PLOS PATHOGENS, 2013, 9 (05):
  • [10] Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo
    Alastruey-Izquierdo, A.
    Mellado, E.
    Pelaez, T.
    Peman, J.
    Zapico, S.
    Alvarez, M.
    Rodriguez-Tudela, J. L.
    Cuenca-Estrella, M.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (07) : 3358 - 3368
12345