Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance

被引：17

作者：

Chen, Bi ^{[1
]}

Ye, Peng ^{[1
]}

Chen, Yeh ^{[2
]}

Liu, Tong ^{[3
,4
]}

Cha, Jong-Ho ^{[5
]}

Yan, Xiuwen ^{[1
]}

Yang, Wen-Hao ^{[1
,6
]}

机构：

[1] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou, Peoples R China

[2] China Med Univ, Inst New Drug Dev, Taichung, Taiwan

[3] Harbin Med Univ, Canc Hosp, Dept Breast Surg, Harbin, Peoples R China

[4] Harbin Med Univ, Inst Canc Prevent & Treatment, Harbin, Peoples R China

[5] Inha Univ, Dept Biomed Sci, Coll Med, Incheon, South Korea

[6] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

基金：

中国国家自然科学基金; 黑龙江省自然科学基金;

关键词：

cancer stem cells; cancer stemness; estrogen; female hormone; progesterone; NEGATIVE BREAST-CANCER; CELL SELF-RENEWAL; ENDOCRINE-THERAPY; RECEPTOR-ALPHA; ER-BETA; DIFFERENTIAL EXPRESSION; ANTIESTROGEN RESISTANCE; INHIBITS PROLIFERATION; STEROID-RECEPTORS; MTOR INHIBITORS;

D O I：

10.3389/fonc.2020.01657

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Estrogen and progesterone regulate the growth and development of human tissues, including the reproductive system and breasts, through estrogen and progesterone receptors, respectively. These receptors are also important indicators for the clinical prognosis of breast cancer and various reproductive cancers. Many studies have reported that cancer stem cells (CSCs) play a key role in tumor initiation, progression, metastasis, and recurrence. Although the role of estrogen and progesterone in human organs and various cancers has been studied, the molecular mechanisms underlying the action of these hormones on CSCs remain unclear. Therefore, further elucidation of the effects of estrogen and progesterone on CSCs should provide a new direction for developing pertinent therapies. In this review, we summarize the current knowledge on the estrogen and progesterone axis involved in cancer stemness and discuss potential therapeutic strategies to inhibit CSCs by targeting relevant pathways.

引用

页数：14

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