Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis

被引:169
作者
Grimstad, Oystein [1 ,2 ]
Sawanobori, Yasushi [3 ]
Vestergaard, Christian [4 ]
Bilsborough, Janine [5 ]
Olsen, Uffe Bang [6 ]
Gronhoj-Larsen, Christian [1 ]
Matsushima, Kouji [3 ]
机构
[1] Norwegian Univ Sci & Technol, Inst Canc Res & Mol Med, N-7030 Trondheim, Norway
[2] Univ Trondheim Hosp, St Olavs Hosp, Dept Dermatol, Trondheim, Norway
[3] Univ Tokyo, Grad Sch Med, Dept Mol Prevent Med, Tokyo, Japan
[4] Aarhus Univ Hosp, Dept Dermatol, DK-8000 Aarhus, Denmark
[5] Dept Immunol, Seattle, WA USA
[6] Novo Nordisk AS, Dept Pharmacol, Malov, Denmark
基金
英国医学研究理事会;
关键词
dermatitis; interleukin-31; NC; Nga; scratch; ITCH-ASSOCIATED RESPONSES; T-CELLS; STREPTOCOCCAL PREPARATION; IGE HYPERPRODUCTION; SKIN-LESION; NC MICE; IL-31; MOUSE; EXPRESSION; IL-18;
D O I
10.1111/j.1600-0625.2008.00766.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Interleukin-31 (IL-31), a novel cytokine, is upregulated in atopic dermatitis skin lesions in humans and skin lesions in the NC/Nga mice, a murine model for atopic dermatitis. Here, we investigated the effect of a monoclonal IL-31 antibody on scratching behaviour, weight gain and dermatitis in NC/Nga mice. Mice were divided into three groups, n = 10 in each group. Mice were given monoclonal IL-31 rat-anti-mouse antibody 10 mg/kg or albumin intraperitoneally every fifth day for seven weeks. In addition, the mice in one group were not exposed to any form of intervention. The dermatitis score was clinically assessed twice a week. The scratching behaviour was automatically detected and objectively evaluated. Intervention with IL-31 antibody 10 mg/kg intraperitoneally every fifth day in NC/Nga mice from age 7 weeks reduced the scratching behaviour, but did not have any impact on weight gain or dermatitis. IL-31 antibody reduces scratching behaviour in an atopic dermatitis-like murine model during the onset of clinical skin manifestations. Our findings suggest IL-31 antibody as a new potential therapeutic approach for pruritus in atopic dermatitis and other pruritic diseases.
引用
收藏
页码:35 / 43
页数:9
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