Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis

被引：198
作者：
Fu, Qiaofen [1 ,2 ]
Chen, Nan [1 ]
Ge, Chunlei [2 ]
Li, Ruilei [2 ]
Li, Zhen [2 ]
Zeng, Baozhen [2 ]
Li, Chunyan [2 ]
Wang, Ying [2 ]
Xue, Yuanbo [2 ]
Song, Xin [2 ]
Li, Heng [1 ]
Li, Gaofeng [1 ]
机构：
[1] Kunming Med Univ, Affiliated Hosp 3, Dept Thorac Surg, Tumor Hosp Yunnan Prov, Kunming, Yunnan, Peoples R China
[2] Kunming Med Univ, Affiliated Hosp 3, Dept Canc Biotherapy Ctr, Tumor Hosp Yunnan Prov, Kunming, Yunnan, Peoples R China
来源：
ONCOIMMUNOLOGY | 2019年 / 8卷 / 07期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Melanoma; prognostic biomarkers; systematic review; tumor-infiltrating lymphocytes (TILs); CUTANEOUS MALIGNANT-MELANOMA; REGULATORY T-CELLS; LYMPH-NODE STATUS; METASTATIC MELANOMA; IMMUNE CELLS; INDEPENDENT PREDICTOR; PD-L1; EXPRESSION; POOR-PROGNOSIS; STAGE-I; SURVIVAL;
D O I：
10.1080/2162402X.2019.1593806
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial whether the presence of TILs is related to an improved prognosis in melanoma. This meta-analysis confirmed the favorable prognostic role of the CD3+, CD4+, CD8+, FOXP3+, and CD20+ TILs in the overall survival of melanoma patients and found an association between the TILs present and improved overall survival. Additionally, subgroup analysis demonstrated that brisk TILs were obviously associated with OS, RFS and DSS/MSS. Thus, TILs may be a predictive biomarker in melanoma. This analysis will provide more insight into the study of TILs and predictive biomarker.
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页数：14
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