Interictal magnetoencephalography used in magnetic resonance imaging-negative patients with epilepsy

被引:17
|
作者
Wu, X. -T. [1 ,2 ]
Rampp, S. [1 ]
Buchfelder, M. [3 ]
Kuwert, T. [4 ]
Bluemcke, I. [5 ]
Doerfler, A. [6 ]
Zhou, D. [2 ]
Stefan, H. [1 ]
机构
[1] Univ Hosp Erlangen, Neurol Clin, D-91054 Erlangen, Germany
[2] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu 610064, Sichuan, Peoples R China
[3] Univ Hosp Erlangen, Dept Neurosurg, D-91054 Erlangen, Germany
[4] Univ Hosp Erlangen, Dept Nucl Med, D-91054 Erlangen, Germany
[5] Univ Hosp Erlangen, Dept Neuropathol, D-91054 Erlangen, Germany
[6] Univ Hosp Erlangen, Dept Neuroradiol, D-91054 Erlangen, Germany
来源
ACTA NEUROLOGICA SCANDINAVICA | 2013年 / 127卷 / 04期
关键词
magnetoencephalography; magnetic resonance imaging; outcome; non-lesional epilepsy;
D O I
10.1111/j.1600-0404.2012.01712.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Wu X-T, Rampp S, Buchfelder M, Kuwert T, Blumcke I, Dorfler A, Zhou D, Stefan H. Interictal magnetoencephalography used in magnetic resonance imaging-negative patients with epilepsy. Acta Neurol Scand: 2013: 127: 274-280. (C) 2012 John Wiley & Sons A/S. Purpose This study aims to investigate the contributions of magnetoencephalography (MEG) in magnetic resonance imaging (MRI)-negative patients. Methods A total of 18 MRI-negative patients diagnosed with refractory epilepsy, subjected to MEG investigation, and subsequently underwent surgery were selected for retrospective analysis. A 1.5-tesla Magnetom Sonata with an eight-channel head array coil was used. MEG data were obtained using a 74/248-channel system. Results A total of 16 patients (16/18) had positive MEG results, comprising 12 patients with monofocal localizations, five with multifocal localizations, and one with unremarkable results in MEG. In addition, 12 patients had indicative single photonemission computed tomography (SPECT), five had indicative fluorodeoxyglucose positron emission tomography (FDG-PET), and all the patients had intracranial electroencephalography (EEG) (14 with subdural electrodes and four with electrocorticography). The intracranial EEG recordings of nine patients were guided by MEG informative results. Among these 18 patients, 10 exhibited good postoperative outcomes (Engel I and II), four of which were completely seizure-free. All these ten patients had clear monofocal localization in MEG, including nine with accordant indicative metabolic changes in either SPECT or FDG-PET, or both. None of the five patients with multifocal localizations achieved good postoperative outcomes. Conclusion For cases with negative MRI findings, epilepsy surgery may be an alternative option for pharmaco-resistant patients if epileptogenic focus localizations by MEG are present in multimodal evaluation.
引用
收藏
页码:274 / 280
页数:7
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