Hydrotalcite: recyclable, novel heterogeneous catalyst for facile, environmentally benign and high yielding multi-component synthesis and mechanistic study under solvent free conditions

被引：38

作者：

Sahu, Pramod Kumar ^{[1
,2
]}

Sahu, Praveen Kumar ^{[2
,3
]}

Jain, Raginee ^{[2
]}

Yadav, Ramjilal ^{[1
]}

Agarwal, Dau Dayal ^{[1
,2
,3
]}

机构：

[1] Jiwaji Univ, Sch Studies Chem, Gwalior 474011, Madhya Pradesh, India

[2] Jiwaji Univ, Dept Ind Chem, Gwalior 474011, Madhya Pradesh, India

[3] Jagdishprasad Jhabarmal Tibrewala Univ, Chudela 333001, Rajasthan, India

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2012年 / 2卷 / 12期

关键词：

ONE-POT SYNTHESIS; CYCLIZATION REACTIONS; POLYTYPE DIVERSITY; FINE CHEMICALS; IONIC LIQUIDS; CONDENSATION; DERIVATIVES; 3-COMPONENT; ANTIBACTERIAL; TOXICITY;

D O I：

10.1039/c2cy20067h

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The synthesis of the 4H-pyrimido[2,1-b][1,3] benzothiazole (1a-1h), 1,2,4-triazoloquinazolines (2a,2b), octahydroquinazolinones (3a,3b) and fused thiazolo[2,3-b] quinazolinone (4a,4b) by multicomponent reactions using aldehydes, dicarbonyl and 2-amino benzothiazole/3-amino-1,2,4-triazole/urea/thiorea has been carried out in the presence of Mg-Al-CO3 and Ca-Al-CO3 hydrotalcite as a heterogeneous catalyst. Hydrotalcites need short reaction times, are non-toxic, easy to work up and reusable under solvent free conditions, hence making this process environment friendly. A detailed mechanistic study shows that the reaction using urea proceeds through imine intermediate 6. In addition, we have isolated and characterized the key intermediate of the reaction by using hydrotalcite.

引用

页码：2465 / 2475

页数：11

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