Epithelial-mesenchymal transition-related factors in solid tumor and hematological malignancy

被引:42
作者
Chou, Yi-Sheng [1 ,2 ,3 ]
Yang, Muh-Hwa [1 ,2 ]
机构
[1] Natl Yang Ming Univ, Sch Med, Inst Clin Med, Taipei 112, Taiwan
[2] Taipei Vet Gen Hosp, Dept Med, Div Hematol & Oncol, Taipei 112, Taiwan
[3] Lotung Poh Ai Hosp, Lo Hsu Fdn, Dept Med, Div Hematol & Oncol, Luodong, Yilan, Taiwan
关键词
epithelial-mesenchymal transition; hematological malignancy; solid tumor; transcription factor; E-CADHERIN REPRESSION; GROUP GENE BMI-1; BREAST-CANCER; TRANSCRIPTION FACTORS; STEM-CELLS; EXPRESSION PATTERNS; CARCINOMA INVASION; TWIST EXPRESSION; REGULATES TWIST; BHLH FACTORS;
D O I
10.1016/j.jcma.2015.05.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The epithelial mesenchymal transition (EMT) process plays pivotal roles in regulatory mechanisms of embryogenesis and wound healing physiologically, and organ fibrosis, cancer progression, and metastasis pathologically. EMT is classified as primary, secondary, and tertiary during embryonic development. EMT contributes to repair of tissue injury and fibrogenesis by re-epithelialization and regeneration of fibroblasts, respectively. The hallmarks of EMT include loss of contact inhibition, remodeling of extracellular matrix, and reorganization of cytoskeleton, along with expression of mesenchymal markers and reduction of epithelial markers. Cancer cells acquire sternness, migration and invasive capability, evade apoptosis, and initiate metastasis to distant organs. Several EMT regulators including Snail, Zeb1, Zeb2, and Twist in solid tumor and Sox4, distal-less homeobox gene 4 (DLX4), Prdm14, Bmi1, and the forkhead box family in hematological malignancy are reviewed with regard to their signaling pathways, regulatory mechanisms, and clinical interactions. Copyright (C) 2015 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.
引用
收藏
页码:438 / 445
页数:8
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