Allergic asthma caused by exposure to bacterial alpha-amylase termamyl®

被引：9

作者：

Baur, Xaver ^{[1
]}

Budnik, Lygia Therese ^{[1
]}

von Kirchbach, Gottfried ^{[2
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Inst Occupat & Maritime Med, Hamburg, Germany

[2] Ambulatory Ctr Pulm Dis & Allergy, Aachen, Germany

来源：

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 2013年 / 56卷 / 03期

关键词：

enzymes; Termamyl (R); occupational asthma; specific IgE; rhinitis; lung function; DETERGENT INDUSTRY; OCCUPATIONAL ASTHMA; BAKING INDUSTRY; ENZYME EXPOSURE; LUNG-FUNCTION; SENSITIZATION; PREVENTION; SMOKING; RISK;

D O I：

10.1002/ajim.22124

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Airborne enzymes behave as potent respiratory allergens. Till date, allergic disorders caused by genetically engineered enzymes widely used in the industry, have not been reported. Results and Conclusions We describe a worker employed in the detergent industry who developed asthma and rhinitis from IgE-mediated sensitization to the thermostable endo-alpha-amylase Termamyl (R) and to the protease Savinase (R). This is the first report showing that Termamyl (R) elicits allergic respiratory disorders in humans. Am. J. Ind. Med. 56:378380, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：378 / 380

页数：3

共 29 条

[1]

[Anonymous], 2010, EFSA SUPPORTING PUBL, DOI DOI 10.2903/SP.EFSA.2010.EN-75

[2]

[Anonymous], 2011, AM C GOVT IND HYGIEN

[3]

Association of Manufacturers of Fermentation Enzyme Products AMFEP, 1994, GUID SAF HANDL MICR

[4] Enzymes as occupational and environmental respiratory sensitisers [J].

Baur, X .

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2005, 78 (04) :279-286

[5]

BAUR X, 1986, LANCET, V1, P43

[6]

Baur X, 1989, IMMUNOL ALLERGY PRAC, V11, P13

[7]

Bernstein IL, 2006, ASTHMA WORKPLACE REL

[8] The prognosis of occupational asthma due to detergent enzymes: clinical, immunological and employment outcomes [J].

Brant, A ;

Zekveld, C ;

Welch, J ;

Jones, M ;

Taylor, AN ;

Cullinan, P .

CLINICAL AND EXPERIMENTAL ALLERGY, 2006, 36 (04) :483-488

[9] Detergent protease exposure and respiratory disease: case-referent analysis of a retrospective cohort [J].

Brant, A. ;

Upchurch, S. ;

van Tongeren, M. ;

Zekveld, C. ;

Helm, J. ;

Barnes, F. ;

Taylor, A. J. Newman ;

Cullinan, P. .

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2009, 66 (11) :754-758

[10] Enzyme exposure, smoking and lung function in employees in the detergent industry over 20 years [J].

Cathcart, M ;

Nicholson, P ;

Roberts, D ;

Bazley, M ;

Juniper, C ;

Murray, P ;

Randell, M .

OCCUPATIONAL MEDICINE-OXFORD, 1997, 47 (08) :473-478

← 1 2 3 →