Synthesis and Suzuki Reactions of N-Heterocyclic Carbene Difluoro(aryl)-boranes

被引：32

作者：

Nerkar, Swapnil ^{[1
]}

Curran, Dennis P. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 14期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

NHC-BORANES; SUBSTITUTION-REACTIONS; COUPLING REACTION; HYDROGEN; BONDS; ORGANOBORANES; HYDROBORATION; FLUORINATION; REDUCTIONS; COMPLEXES;

D O I：

10.1021/acs.orglett.5b01101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Readily available NHC-arylboranes (NHC-BH2Ar) are converted in high yield to stable NHC-difluoro(aryl)boranes (NHC-BF2Ar) by treatment with 2; equiv of 1-chloromethyl-4-fluoro-1,4-diazonia-bicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor). In turn, the NHC-difluoro(aryl)boranes participate directly in Suzuki reactions under conditions previously used for anionic trifluoroborate salts. Accordingly; NHC-difluoroboranes are a new class of stable precursors for Suzuki reactions.

引用

页码：3394 / 3397

页数：4

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