Mitochondrial DNA variants influence mitochondrial bioenergetics in Drosophila melanogaster

被引：46

作者：

Correa, C. C. ^{[1
]}

Aw, Wc ^{[1
]}

Melvin, R. G. ^{[2
]}

Pichaud, N. ^{[1
]}

Ballard, J. W. O. ^{[1
]}

机构：

[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[2] Univ Helsinki, Inst Biotechnol, Bioctr 3, FIN-00014 Helsinki, Finland

来源：

MITOCHONDRION | 2012年 / 12卷 / 04期

关键词：

Mitochondrial bioenergetics; Reactive oxygen species; mtDNA copy number; ORGANISMAL PHENOTYPE; ACID DELETION; SIMULANS; CELLS; OXIDASE; LIFE; RESPIRATION; DYSFUNCTION; METABOLISM; MUTATIONS;

D O I：

10.1016/j.mito.2012.06.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The influence of mitochondrial DNA (mtDNA) mutations on human disease has been extensively studied, but the impact of mutations within the adaptive range is debated. We studied males from lines of Drosophila melanogaster that have a highly standardized nuclear genome but different mtDNA, at two ages. We measured mitochondrial respiration on permeabilized muscle fibers, hydrogen peroxide production of isolated mitochondria and mtDNA copy number of whole individuals. The results show that a small set of naturally occurring mtDNA mutations can have a significant influence on mitochondrial bioenergetics that may change as the organism ages. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：459 / 464

页数：6

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