Is there a best graft source of transplantation in acute myeloid leukemia?

被引：7

作者：

Ballen, Karen K. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[2] Massachusetts Gen Hosp, Dept Med, Div Hematol Oncol, Boston, MA 02114 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2015年 / 28卷 / 2-3期

关键词：

Acute myeloid leukemia; AML; Haploidentical transplant; Umbilical cord blood transplantation; Unrelated donor transplantation; UMBILICAL-CORD BLOOD; HEMATOPOIETIC-CELL TRANSPLANTATION; ALTERNATIVE DONOR TRANSPLANTATION; MISMATCHED UNRELATED DONOR; ACUTE MYELOGENOUS LEUKEMIA; HOST-DISEASE PROPHYLAXIS; REDUCED-INTENSITY; HEMATOLOGIC MALIGNANCIES; MARROW-TRANSPLANTATION; OLDER PATIENTS;

D O I：

10.1016/j.beha.2015.10.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Only 30% of patients in the US who require an allogeneic hematopoietic cell transplant will have a fully HLA matched sibling donor. The National Marrow Donor Program/Be the Match has grown to over 25 million unrelated donors. However, a fully matched unrelated donor may not be available for many patients, particularly for patients of diverse racial and ethnic backgrounds. Over the last 10 years, considerable progress has been made in alternative donor transplant with improvements in outcomes for umbilical cord blood (UCB), haploidentical (haplo) related donor, and mismatched unrelated donor (MMUD) for patients with acute myeloid leukemia. Retrospective studies indicate comparable survival for these three graft sources. In this chapter, we review the latest results for patients receiving alternative donor transplants, and discuss strategies for choosing the optimal donor for each individual patient. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：147 / 154

页数：8

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