Zinc binding groups for histone deacetylase inhibitors

被引：183

作者：

Zhang, Lei ^{[1
]}

Zhang, Jian ^{[1
]}

Jiang, Qixiao ^{[2
]}

Zhang, Li ^{[2
]}

Song, Weiguo ^{[1
]}

机构：

[1] Weifang Med Univ, Sch Pharm, Dept Med Chem, Weifang, Shandong, Peoples R China

[2] Qingdao Univ, Sch Pharm, Qingdao, Shandong, Peoples R China

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2018年 / 33卷 / 01期

关键词：

Histone deacetylase inhibitor; zinc binding group; anti-tumour; selectivity; drug design; PHASE-I; CARDIAC-HYPERTROPHY; VALPROIC ACID; ORAL CI-994; POTENT; COMBINATION; IDENTIFICATION; MGCD0103; CANCER; ST7612AA1;

D O I：

10.1080/14756366.2017.1417274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency of HDACIs. Due to the high affinity to the zinc ion, hydroxamic acid is the most commonly used ZBG in the structure of HDACs. An alternative ZBG is benzamide group, which features excellent inhibitory selectivity for class I HDACs. Various ZBGs have been designed and tested to improve the activity and selectivity of HDACIs, and to overcome the pharmacokinetic limitations of current HDACIs. Herein, different kinds of ZBGs are reviewed and their features have been discussed for further design of HDACIs.

引用

页码：714 / 721

页数：8

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