Bisensitive core-shell nanohydrogels by e-Beam irradiation of micelles

被引：16
作者：
Picos-Corrales, Lorenzo A. [1 ]
Licea-Claverie, Angel [1 ]
Arndt, Karl-Friedrich [2 ]
机构：
[1] Ctr Grad & Invest Quim, Inst Tecnol Tijuana, Tijuana 22510, BC, Canada
[2] Tech Univ Dresden, D-01062 Dresden, Germany
来源：
REACTIVE & FUNCTIONAL POLYMERS | 2014年 / 75卷
关键词：
Block copolymers; e-Beam irradiation; Nanogels; Micelles; Light scattering; BLOCK-COPOLYMERS; N-ISOPROPYLACRYLAMIDE; CROSS-LINKING; DISPERSION POLYMERIZATION; BIOMEDICAL APPLICATIONS; STAR COPOLYMERS; MIXED MICELLES; ACID MONOMERS; NANOGELS; PH;
D O I：
10.1016/j.reactfunctpolym.2013.11.010
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Sensitive nanohydrogels based on micellar aggregates from amphiphilic block copolymers were synthesized by means of electron beam irradiation. The crosslinked shell consists of temperature sensitive [N-isopropylacrylamide (NIPAAm)] and pH sensitive [5-methacryloyloxy pentatonic acid (5MPA) or 4-methacryloyloxy benzoic acid (4MBA)] units, while the core is a hydrophobic network that may work as a reservoir for drugs. The effect of the irradiation dose and the polymer concentration were tested. Dynamic and static light scattering were combined to investigate the morphology of aggregates prior and after irradiation to obtain nanohydrogels. Hydrodynamic radius of nanogels is in the range from 18 to 44 nm. rho-Parameter suggests that crosslinked aggregates of flexible chains were obtained. Mixtures of block copolymers with different phase transition behavior in each aggregate lead to the preparation of nanohydrogels with tailored phase transition behavior. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：31 / 40
页数：10
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