How cells change their phenotype

被引：300

作者：

Tosh, D ^{[1
]}

Slack, JMW ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Dev Biol Programme, Bath BA2 7AY, Avon, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 03期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nrm761

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent attention has focused on the remarkable ability of adult stem cells to produce differentiated cells from embryologically unrelated tissues. This phenomenon is an example of metaplasia and shows that embryological commitments can be reversed or erased under certain circumstances. In some cases, even fully differentiated cells can change their phenotype (transdifferentiation). This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.

引用

页码：187 / 194

页数：8

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