Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats

被引：20

作者：

Fahmi, Abdelgawad A. ^{[1
]}

Abdur-Rahman, Mariam ^{[1
]}

Naser, Asmaa F. Aboul ^{[2
]}

Hamed, Manal A. ^{[2
]}

Abd-Alla, Howaida, I ^{[3
]}

Shalaby, Nagwa M. M. ^{[3
]}

Nasr, Mohamed, I ^{[4
]}

机构：

[1] Cairo Univ, Fac Sci, Chem Dept, Cairo, Egypt

[2] Natl Res Ctr, Dept Therapeut Chem, Giza, Egypt

[3] Natl Res Ctr, Chem Nat Cpds Dept, Giza, Egypt

[4] Cairo Specialized Hosp, Clin Pathol Lab, Cairo, Egypt

来源：

HELIYON | 2019年 / 5卷 / 03期

关键词：

Biochemistry; OXIDATIVE STRESS; MUCOSAL DAMAGE; SEED EXTRACT; GLUTATHIONE; CRISPA; ACID; ANTIOXIDANT; MODULATION; SELENIUM; MODEL;

D O I：

10.1016/j.heliyon.2019.e01359

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pulicaria undulata subsp. undulata (Family; Asteraceae) is a medicinal plant used to treat inflammation. The objective of this study is to explore the protective effect of the ethanol extract of P. undulata subsp. undulata aerial parts against ethanol induced gastric ulcer in rats. The chemical composition of plant extract, the unsaponifiable matter and the fatty acid methyl esters were analyzed. The biological evaluation was carried out through measuring ulcer indices, oxidative stress markers, certain marker enzymes, inflammatory index and the histopathological assessment of the stomach in rats. The total unsaponifiable matter (94.29%) and the fatty acid methyl ester (82.96%) content were identified. Gastric ulcer recorded significant increase in gastric volume and lesion counts (p < 0.0001). Drastic changes in all biochemical parameters under investigation were observed. Protection with plant extract reversed the action of ethanol by variable degrees of improvement in comparison with the reference drug. The presence of carbohydrates and proteins that acted as a mucilage lining the stomach inner wall give its protective action. In conclusion, P. undulata subsp. undulata succeeded to have anti-ulcerative protective effect. The measured biomarkers served as a good mirror to predict gastric ulcer and the presence of carbohydrates, protein and fibers present in the plant extract acted as a mucilage lining the inner intestinal wall and protect against ethanol induced gastric ulcer. Future study will be carried out to identify the biologically active compounds responsible for plant protection against the gastric ulcer.

引用

页数：25

共 56 条

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