Expression of Genes of Glutathione Transferase Isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in Tumor Cells during the Formation of Drug Resistance to Cisplatin

被引：24
作者：
Kalinina, E. V. [1 ]
Berozov, T. T. [1 ]
Shtil, A. A. [2 ]
Chernov, N. N. [1 ]
Glasunova, V. A. [2 ]
Novichkova, M. D. [1 ]
Nurmuradov, N. K. [1 ]
机构：
[1] Peoples Friendship Univ Russia, Moscow, Russia
[2] Russian Acad Med Sci, NN Blokhin Russian Canc Res Ctr, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 154卷 / 01期
关键词：
drug resistance of tumor cells; gene expression; glutathione-S-transferase isoforms; cisplatin; S-TRANSFERASE; OXIDATIVE STRESS; LUNG;
D O I：
10.1007/s10517-012-1876-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the expression of genes encoding glutathione-S-transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 during the development of the resistance of human erythroleukemia (K562), mammary adenocarcinoma (MCF-7) and ovary adenocarcinoma (SKOV-3) cells to cisplatin (CDDP). It was found that drug resistance development in all three strains of tumor cells is associated with signifi cant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant K562/CDDP and MCF-7/CDDP cells.
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页码：64 / 67
页数：4
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