Detection of Glucose in the Human Brain with 1H MRS at 7 Tesla

被引：10

作者：

Kaiser, Lana G. ^{[1
]}

Hirokazu, Kawaguchi ^{[1
]}

Fukunaga, Masaki ^{[2
]}

Matson, Gerald B. ^{[3
]}

机构：

[1] Siemens Healthcare KK, Tokyo, Japan

[2] Natl Inst Physiol Sci, Okazaki, Aichi, Japan

[3] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2016年 / 76卷 / 06期

关键词：

MRS; glucose; 7; Tesla; jedit-SLASER; numerical simulations; human brain; C-13; NMR-SPECTROSCOPY; IN-VIVO; METABOLISM; SIMULATION; 4T;

D O I：

10.1002/mrm.26456

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: A new method is proposed for noninvasive detection of glucose in vivo using proton MR spectroscopy at 7 Tesla. Theory and Methods: The proposed method utilizes J-difference editing to uncover the resonance of beta-glucose (beta-glc) at 3.23 ppm, which is strongly overlapped with choline. Calculations using the density matrix formalism are used to maximize the signal-to-noise ratio of the b-glc resonance at 3.23 ppm. The calculations are verified using phantom and in vivo data collected at 7 Tesla. Results: The proposed method allows observation of the glucose signal at 3.23 ppm in the human brain spectrum. Additional co-edited resonances of N-acetylaspartylglutamatate and glutathione are also detected in the same experiment. Conclusion: The proposed method does not require carbon (C-13)-labeled glucose injections and C-13 hardware; as such, it has a potential to provide valuable information on intrinsic glucose concentration in the human brain in vivo. (C) 2016 International Society for Magnetic Resonance in Medicine

引用

页码：1653 / 1660

页数：8

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