Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis

被引：52

作者：

Zhang, W

Curran, DP

Chen, CHT

机构：

[1] Fluorous Technol Inc, Pittsburgh, PA 15238 USA

[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

TETRAHEDRON | 2002年 / 58卷 / 20期

关键词：

fluorous; scavengers; thiol quenching; solid phase extraction; parallel synthesis;

D O I：

10.1016/S0040-4020(02)00209-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general fluorous thiol quenching method is introduced. Excess alpha-bromoketones or benzyl bromides in parallel N-alkylation reactions are quenched with a fluorous thiol (C6F13CH2CH2SH). The resulting fluorous derivatives can be separated from the reaction mixture by a solid phase extraction on fluorous silica gel. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3871 / 3875

页数：5

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