MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

被引：518

作者：

van Rooij, Eva ^{[2
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[2] MiRagen Therapeut, Boulder, CO 80301 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2012年 / 11卷 / 11期

关键词：

IN-VIVO; COLLAGEN EXPRESSION; CARDIAC-HYPERTROPHY; GENE-EXPRESSION; RENAL FIBROSIS; MESSENGER-RNAS; UP-REGULATION; HUMAN HEART; CELL; INHIBITION;

D O I：

10.1038/nrd3864

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and function through systemic or local delivery of miRNA inhibitors, referred to as antimiRs, has triggered enthusiasm for miRNAs as novel therapeutic targets. Here, we focus on the pharmacokinetic and pharmacodynamic properties of current antimiR designs and their relevance to cardiovascular indications, and evaluate the opportunities and obstacles associated with this new therapeutic modality.

引用

页码：860 / 872

页数：13

共 107 条

[1] PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy [J].

Ardite, Esther ;

Perdiguero, Eusebio ;

Vidal, Berta ;

Gutarra, Susana ;

Serrano, Antonio L. ;

Munoz-Canoves, Pura .

JOURNAL OF CELL BIOLOGY, 2012, 196 (01) :163-175

[2] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[3] Cardiovascular Importance of the MicroRNA-23/27/24 Family [J].

Bang, Claudia ;

Fiedler, Jan ;

Thum, Thomas .

MICROCIRCULATION, 2012, 19 (03) :208-214

[4] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[5] Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat [J].

Bish, Lawrence T. ;

Morine, Kevin ;

Sleeper, Meg M. ;

Sanmiguel, Julio ;

Wu, Di ;

Gao, Guangping ;

Wilson, James M. ;

Sweeney, H. Lee .

HUMAN GENE THERAPY, 2008, 19 (12) :1359-1368

[6] Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster [J].

Boettger, Thomas ;

Beetz, Nadine ;

Kostin, Sawa ;

Schneider, Johanna ;

Krueger, Marcus ;

Hein, Lutz ;

Braun, Thomas .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (09) :2634-2647

[7] Vascular microRNAs [J].

Bonauer, Angelika ;

Boon, Reinier A. ;

Dimmeler, Stefanie .

CURRENT DRUG TARGETS, 2010, 11 (08) :943-949

[8] MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice [J].

Bonauer, Angelika ;

Carmona, Guillaume ;

Iwasaki, Masayoshi ;

Mione, Marina ;

Koyanagi, Masamichi ;

Fischer, Ariane ;

Burchfield, Jana ;

Fox, Henrik ;

Doebele, Carmen ;

Ohtani, Kisho ;

Chavakis, Emmanouil ;

Potente, Michael ;

Tjwa, Marc ;

Urbich, Carmen ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

SCIENCE, 2009, 324 (5935) :1710-1713

[9] MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation [J].

Boon, Reinier A. ;

Seeger, Timon ;

Heydt, Susanne ;

Fischer, Ariane ;

Hergenreider, Eduard ;

Horrevoets, Anton J. G. ;

Vinciguerra, Manlio ;

Rosenthal, Nadia ;

Sciacca, Sergio ;

Pilato, Michele ;

van Heijningen, Paula ;

Essers, Jeroen ;

Brandes, Ralf P. ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

CIRCULATION RESEARCH, 2011, 109 (10) :1115-U66

[10] MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice [J].

Callis, Thomas E. ;

Pandya, Kumar ;

Seok, Hee Young ;

Tang, Ru-Hang ;

Tatsuguchi, Mariko ;

Huang, Zhan-Peng ;

Chen, Jian-Fu ;

Deng, Zhongliang ;

Gunn, Bronwyn ;

Shumate, Janelle ;

Willis, Monte S. ;

Selzman, Craig H. ;

Wang, Da-Zhi .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (09) :2772-2786

← 1 2 3 4 5 6 7 8 9 10 →