Photo-induced anti-inflammatory activities of chloro substituted subphthalocyanines on the mammalian macrophage in vitro

被引：18

作者：

Ayaz, Furkan ^{[1
]}

Ugur, Naz ^{[2
]}

Ocakoglu, Kasim ^{[3
]}

Ince, Mine ^{[3
]}

机构：

[1] Mersin Univ, Fac Arts & Sci, Dept Biotechnol, TR-33110 Yenisehir, Mersin, Turkey

[2] Mersin Univ, Adv Technol Res & Applicat Ctr, Ciftlikkoy Campus, TR-33343 Mersin, Turkey

[3] Tarsus Univ, Dept Energy Syst Engn, Fac Engn, Tarsus, Mersin, Turkey

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2019年 / 25卷

关键词：

Inflammation; macrophages; immunomodulatory agents; suphthalocyanines; anti-inflammatory agents; Photodynamic therapy; TOLL-LIKE RECEPTORS; PHOTODYNAMIC THERAPY; MURINE MACROPHAGE; IMMUNITY; BORON; INFLAMMATION; CANCER; IMMUNOMODULATION; LIGANDS; CELLS;

D O I：

10.1016/j.pdpdt.2019.02.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, a series of subphthalocyanines (SubPcs) derivatives were synthesized to generate unique immunomodulatory molecules that can be activated through photo-induction. Immunomodulatory agents have a great potential in medicine to manipulate the immune system according to our needs and prevent disease symptoms. Inflammation is one of these symptoms and macrophages play a crucial role in the generation of inflammatory responses. Being able to control the activity of these agents through photo-induction enables the fine tuning on their activities in a location specific and non-invasive manner with possibly minor side effects. Mammalian macrophages' pro-inflammatory activity was examined in the presence of our compounds as well as LPS as a danger mimic. These compounds exerted photo-induced anti-inflammatory activities on the macrophages. Number of Cl atoms was a defining factor in their photo-induced anti-inflammatory immunomodulatory efficiencies.

引用

页码：499 / 503

页数：5

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