Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase

被引：71

作者：

Iwatate, Ryu J. ^{[1
,5
,6
]}

Kamiya, Mako ^{[1
,3
]}

Umezawa, Keitaro ^{[2
]}

Kashima, Hiroki ^{[1
]}

Nakadate, Mamiko ^{[1
]}

Kojima, Ryosuke ^{[1
]}

Urano, Yasuteru ^{[1
,2
,4
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

[4] Japan Agcy Med Res & Dev, AMED CREST, Chiyoda Ku, 1-7-1 Otemachi, Tokyo 1000004, Japan

[5] Nagoya Univ, Sch Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan

[6] Nagoya Univ, Inst Transformat Biomol WPI ITbM, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648602, Japan

来源：

BIOCONJUGATE CHEMISTRY | 2018年 / 29卷 / 02期

关键词：

SQUAMOUS-CELL CARCINOMA; IN-VIVO; RATIONAL DESIGN; CANCER; TRANSPEPTIDASE; GREEN; MODEL;

D O I：

10.1021/acs.bioconjchem.7b00776

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We designed and synthesized an activatable near infrared (NIR) fluorescent probe for gamma-glutamyltransferase, based on an asymmetric silicon rhodamine scaffold with an optimized equilibrium of intramolecular spirocyclization. The synthesized probe exhibits dramatic NIR fluorescence activation and, in combination with previously reported probes, enables discrimination of tumors with different enzymatic profiles.

引用

收藏

页码：241 / 244

页数：4

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