Protective Capacity of Virus-Specific T Cell Receptor-Transduced CD8 T Cells In Vivo

被引：6

作者：

Mueller, Katja ^{[1
]}

von Maessenhausen, Anne ^{[1
]}

Aichele, Ulrike ^{[1
]}

Staerck, Lilian ^{[2
]}

Leisegang, Matthias ^{[2
]}

Uckert, Wolfgang ^{[2
,3
]}

Pircher, Hanspeter ^{[1
]}

机构：

[1] Univ Freiburg, Inst Med Microbiol & Hyg, Dept Immunol, D-79106 Freiburg, Germany

[2] Max Delbruck Ctr Mol Med, Berlin, Germany

[3] Humboldt Univ, Inst Biol, D-10099 Berlin, Germany

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 19期

关键词：

LYMPHOCYTIC CHORIOMENINGITIS; GENE-THERAPY; ANTIGEN; MEMORY; REQUIREMENT; MICE;

D O I：

10.1128/JVI.01472-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.

引用

页码：10866 / 10869

页数：4

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