Bioactivity of extracts of Musa paradisiaca L. obtained with compressed propane and supercritical CO2

被引：21

作者：

Correa, Madeline ^{[1
]}

Bombardelli, Michele C. M. ^{[2
]}

Fontana, Pamela Dias ^{[4
]}

Bovo, Fernanda ^{[3
,4
]}

Messias-Reason, Iara Jose ^{[4
]}

Baron Maurer, Juliana Bello ^{[3
]}

Corazza, Marcos Lucio ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Chem Engn, BR-81531990 Curitiba, Parana, Brazil

[2] State Univ Midwest, Dept Food Engn, BR-85040080 Guarapuava, PR, Brazil

[3] Univ Fed Parana, Dept Biochem & Mol Biol, NUPPLAMED, POB 19046, BR-81531900 Curitiba, Parana, Brazil

[4] Univ Fed Parana, Dept Med Pathol, BR-80060900 Curitiba, Parana, Brazil

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2017年 / 122卷

关键词：

Antioxidant activity; Antibacterial activity; Anti-complement activity; Anti-inflammatory; Banana; GINGER ZINGIBER-OFFICINALE; ANTIOXIDANT ACTIVITY; CARBON-DIOXIDE; CHEMICAL-COMPOSITION; FLUID EXTRACTION; OIL; ANTIBACTERIAL; PERSPECTIVES; ECULIZUMAB; CAPACITY;

D O I：

10.1016/j.supflu.2016.12.004

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This paper reports the assessment of bioactivity of inflorescences extracts of Musa paradisiaca L. obtained using supercritical CO2 (scCO(2)) and compressed propane as solvents. The effects of extraction conditions over the antioxidant and antibacterial activity were evaluated. The highest antioxidant activity (3576.86 +/- 18.36 mg of a-tocopherol/g extract) was found for extracts obtained using scCO(2) as solvent at 353.15 K and 25.0 MPa. The extracts did not showed inhibitionfor the bacteria tested. The immunomodulatory effects of the extracts obtained by the extraction with 308.15 K and 3.0 MPa showed a significant inhibitory effect on the alternative pathway (AP) in all concentrations tested (333-5.2 mu g mL(-1)), with at least 70% reduction in the AP-induced haemolysis when compared with the 100% haemolysis control without the use of the extract. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：63 / 69

页数：7

共 68 条

[1]

Agarwal PK, 2009, INDIAN J EXP BIOL, V47, P32

[2] Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens [J].

Ahmad, I ;

Beg, AZ .

JOURNAL OF ETHNOPHARMACOLOGY, 2001, 74 (02) :113-123

[3] Differentiation between the complement modulating effects of an arabinogalactan-protein from Echinacea purpurea and heparin [J].

Alban, S ;

Classen, B ;

Brunner, G ;

Blaschek, W .

PLANTA MEDICA, 2002, 68 (12) :1118-1124

[4] Optimization of antibacterial activity of Eucalyptus tereticornis leaf extracts against Escherichia coli through response surface methodology [J].

Ammer, Muhammad Rifaqat ;

Zaman, Shah ;

Khalid, Muhammad ;

Bilal, Muhammad ;

Erum, Shazia ;

Huang, Danfeng ;

Che, Shengquan .

JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES, 2016, 9 (04) :376-385

[5]

[Anonymous], 2010, SCI TECHNOLOGIE ALIM

[6]

BAUER AW, 1966, AM J CLIN PATHOL, V45, P493

[7]

Biswas S. K., 2011, Journal of Applied Pharmaceutical Science, V1, P133

[8] Neutralizing properties of Musa paradisiaca L. (Musaceae) juice on phospholipase A2, myotoxic, hemorrhagic and lethal activities of crotalidae venoms [J].

Borges, MH ;

Alves, DLF ;

Raslan, DS ;

Piló-Veloso, D ;

Rodrigues, VM ;

Homsi-Brandeburgo, MI ;

de Lima, ME .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 98 (1-2) :21-29

[9]

Bovo F., 2013, Patent deposit, Patent No. [BR1020130305871, 1020130305871, BR 1020130305871]

[10] Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria [J].

Brodsky, Robert A. ;

Young, Neal S. ;

Antonioli, Elisabetta ;

Risitano, Antonio M. ;

Schrezenmeier, Hubert ;

Schubert, Jorg ;

Gaya, Anna ;

Coyle, Luke ;

De Castro, Carlos ;

Fu, Chieh-Lin ;

Maciejewski, Jaroslaw P. ;

Bessler, Monica ;

Kroon, Henk-Andre ;

Rother, Russell P. ;

Hillmen, Peter .

BLOOD, 2008, 111 (04) :1840-1847

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