Time-course of lipid peroxidation in different organs of mice treated with Echis pyramidum snake venom

被引:24
作者
Al Asmari, A
Al Moutaery, K
Manthari, RA
Khan, HA
机构
[1] Armed Forces Hosp, Res Ctr, Riyadh 11159, Saudi Arabia
[2] Armed Forces Hosp, Dept Neurosurg, Riyadh 11159, Saudi Arabia
[3] King Saud Univ, Coll Sci, Dept Biochem, Riyadh, Saudi Arabia
关键词
snake venom; Echis pyramidum; lipid peroxidation; malondialdehyde; mice;
D O I
10.1002/jbt.20121
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study examined the effect of Echis pyramidion (EP) venom on time-course of lipid peroxidation in different vital organs of mice. Adult male Swiss albino mice were injected with EP venom (2 mg/kg, i.p.); control mice received vehicle alone (normal saline). Mice were killed at 1, 3, 6, 12, and 24 h postenvenomation. The liver, lung, kidney, heart, and brain (cerebrum and cerebellum) were collected for the estimation of malondialdehyde (MDA), an index of lipid peroxidation. The results of this study showed that a single injection of EP venom caused a significant lipid peroxidation in all the organs studied. The onset of lipid peroxidation was as early as 1 h and persisted for several hours, suggesting an important role of oxidative stress in the cytotoxicity of EP venom. (c) 2006 Wiley Periodicals, Inc.
引用
收藏
页码:93 / 95
页数:3
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