Minimotif Miner: a tool for investigating protein function

被引：99
作者：
Balla, S
Thapar, V
Verma, S
Luong, T
Faghri, T
Huang, CH
Rajasekaran, S
del Campo, JJ
Shinn, JH
Mohler, WA
Maciejewski, MW
Gryk, MR
Piccirillo, B
Schiller, SR
Schiller, MR [1 ]
机构：
[1] Univ Connecticut, Dept Comp Sci & Engn, Storrs, CT 06269 USA
[2] Univ Connecticut, Hlth Ctr, Dept Genet & Dev Biol, Farmington, CT 06030 USA
[3] Univ Connecticut, Hlth Ctr, Dept Mol Microbial & Struct Biol, Farmington, CT 06030 USA
[4] Univ Connecticut, Hlth Ctr, Dept Neurosci, Farmington, CT 06030 USA
来源：
NATURE METHODS | 2006年 / 3卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nmeth856
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In addition to large domains, many short motifs mediate functional post-translational modification of proteins as well as protein-protein interactions and protein trafficking functions. We have constructed a motif database comprising 312 unique motifs and a web-based tool for identifying motifs in proteins. Functional motifs predicted by MnM can be ranked by several approaches, and we validated these scores by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifs in EFF-1.
引用
收藏
页码：175 / 177
页数：3
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