Expression and function of cell adhesion molecules during neural crest migration

被引:55
|
作者
McKeown, Sonja J. [1 ]
Wallace, Adam S. [1 ]
Anderson, Richard B. [1 ]
机构
[1] Univ Melbourne, Dept Anat & Neurosci, Melbourne, Vic 3010, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
Neural crest; Cell adhesion; Migration; Mouse; Chick; Xenopus; ENTERIC NERVOUS-SYSTEM; EPITHELIAL-MESENCHYMAL TRANSITION; XENOPUS-LAEVIS DEVELOPMENT; CARDIAC OUTFLOW TRACT; HUMAN-MELANOMA CELLS; N-CADHERIN; AVIAN EMBRYO; BETA-CATENIN; MATRIX METALLOPROTEINASES; HIRSCHSPRUNG-DISEASE;
D O I
10.1016/j.ydbio.2012.10.028
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neural crest cells are highly migratory cells that give rise to many derivatives including peripheral ganglia, craniofacial structures and melanocytes. Neural crest cells migrate along defined pathways to their target sites, interacting with each other and their environment as they migrate. Cell adhesion molecules are critical during this process. In this review we discuss the expression and function of cell adhesion molecules during the process of neural crest migration, in particular cadherins, integrins, members of the immunoglobulin superfamily of cell adhesion molecules, and the proteolytic enzymes that cleave these cell adhesion molecules. The expression and function of these cell adhesion molecules and proteases are compared across neural crest emigrating from different axial levels, and across different species of vertebrates. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:244 / 257
页数:14
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