Molecular allergology approach to allergic diseases in the paediatric age

被引：14
作者：
Alessandri, Claudia [1 ]
Zennaro, Danila [1 ]
Zaffiro, Alessandra [1 ]
Mari, Adriano [1 ]
机构：
[1] IDI IRCCS, Ctr Clin & Expt Allergol, Rome, Italy
来源：
ITALIAN JOURNAL OF PEDIATRICS | 2009年 / 35卷
关键词：
CLASS-I CHITINASES; LATEX-FRUIT SYNDROME; SKIN PRICK TEST; CROSS-REACTIVE ALLERGEN; LIPID-TRANSFER PROTEIN; HEVEIN-LIKE DOMAIN; IMMUNOLOGICAL CHARACTERIZATION; RECOMBINANT ALLERGENS; POLLEN SENSITIZATION; MAJOR ALLERGEN;
D O I：
10.1186/1824-7288-35-29
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Identification, characterization, and purification of allergens are essential for the structural and immunologic studies needed to understand how these molecules induce specific IgE antibody production by the human immune system. Advances in molecular biology techniques have led to the production of recombinant allergens having constant properties, allowing detection of specific IgE directed against different molecular components of an allergenic source. Presence of homologous allergens in different sources is the reason for cross-reaction. Molecule-based diagnostic tools can lead to better interpretation of poly-sensitizations, observed by ST and in vitro tests using allergenic extracts as they were made before. Some examples IgE sensitization to major genuine allergens and panallergens will be presented.
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页数：12
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共 80 条
[1]   Cross-reactivity of IgE antibodies to allergens [J].
Aalberse, RC ;
Akkerdaas, JH ;
van Ree, R .
ALLERGY, 2001, 56 (06) :478-490
[2]   Assessment of allergen cross-reactivity [J].
Rob C Aalberse .
Clinical and Molecular Allergy, 5 (1)
[3]   In silico predictability of allergenicity:: From amino acid sequence via 3-D structure to allergenicity [J].
Aalberse, Rob C. ;
Stadler, Beda M. .
MOLECULAR NUTRITION & FOOD RESEARCH, 2006, 50 (07) :625-627
[4]   Assessing allergen levels in peach and nectarine cultivars [J].
Ahrazem, Oussama ;
Jimeno, Lucia ;
Lopez-Torrejon, Gema ;
Herrero, Maria ;
Espada, Jose L. ;
Sanchez-Monge, Rosa ;
Duffort, Oscar ;
Barber, Domingo ;
Salcedo, Gabriel .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2007, 99 (01) :42-47
[5]   How accurate and safe is the diagnosis of hazelnut allergy by means of commercial skin prick test reagents? [J].
Akkerdaas, JH ;
Wensing, M ;
Knulst, AC ;
Krebitz, M ;
Breiteneder, H ;
de Vries, S ;
Penninks, AH ;
Aalberse, RC ;
Hefle, SL ;
van Ree, R .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2003, 132 (02) :132-140
[6]   Component-resolved diagnosis with recombinant allergens in patients with cherry allergy [J].
Ballmer-Weber, BK ;
Scheurer, S ;
Fritsche, P ;
Enrique, E ;
Cistero-Bahima, A ;
Haase, T ;
Wüthrich, B .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 110 (01) :167-173
[7]   Mapping of IgE-binding epitopes on the major latex allergen Hev b 2 and the cross-reacting 1,3β-glucanase fruit allergens as a molecular basis for the latex-fruit syndrome [J].
Barre, Annick ;
Culerrier, Raphael ;
Granier, Claude ;
Selman, Laetitia ;
Peumans, Willy J. ;
Van Damme, Els J. M. ;
Bienvenu, Francoise ;
Bienvenu, Jacques ;
Rouge, Pierre .
MOLECULAR IMMUNOLOGY, 2009, 46 (8-9) :1595-1604
[8]   IgE epitope analysis of the hevein preprotein; A major latex allergen [J].
Beezhold, DH ;
Kostyal, DA ;
Sussman, GL .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1997, 108 (01) :114-121
[9]   Class I chitinases as potential panallergens involved in the latex-fruit syndrome [J].
Blanco, C ;
Diaz-Perales, A ;
Collada, C ;
Sánchez-Monge, R ;
Aragoncillo, C ;
Castillo, R ;
Ortega, N ;
Alvarez, M ;
Carrillo, T ;
Salcedo, G .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (03) :507-513
[10]   AVOCADO HYPERSENSITIVITY [J].
BLANCO, C ;
CARRILLO, T ;
CASTILLO, R ;
QUIRALTE, J ;
CUEVAS, M .
ALLERGY, 1994, 49 (06) :454-459
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