Future Challenges in Cancer Resistance to Immunotherapy

被引：53

作者：

van Elsas, Marit J. ^{[1
]}

van Hall, Thorbald ^{[1
]}

van der Burg, Sjoerd H. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Oncode Inst, Dept Med Oncol, NL-2300 RC Leiden, Netherlands

来源：

CANCERS | 2020年 / 12卷 / 04期

关键词：

immunotherapy; primary resistance; secondary resistance; TUMOR RESPONSE DYNAMICS; SQUAMOUS-CELL CARCINOMA; ANTIGEN CLASS-I; PD-1; BLOCKADE; ACQUIRED-RESISTANCE; TGF-BETA; IMMUNE EVASION; T-CELLS; MELANOMA; EXPRESSION;

D O I：

10.3390/cancers12040935

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer immunotherapies, including checkpoint inhibitors, adoptive T cell transfer and therapeutic cancer vaccines, have shown promising response rates in clinical trials. Unfortunately, there is an increasing number of patients in which initially regressing tumors start to regrow due to an immunotherapy-driven acquired resistance. Studies on the underlying mechanisms reveal that these can be similar to well-known tumor intrinsic and extrinsic primary resistance factors that precluded the majority of patients from responding to immunotherapy in the first place. Here, we discuss primary and secondary immune resistance and point at strategies to identify potential new mechanisms of immune evasion. Ultimately, this may lead to improved immunotherapy strategies with improved clinical outcomes.

引用

页数：16

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