Controlled acetylation of water-soluble glucomannan from Bletilla striata

被引：47

作者：

Liu, Jiang-yun ^{[1
]}

Wang, Hu-cheng ^{[1
]}

Yin, Yin ^{[1
]}

Li, Nan ^{[1
]}

Cai, Pei-lie ^{[1
]}

Yang, Shi-lin ^{[1
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 89卷 / 01期

关键词：

Glucomannan; Bletilla striata; Acetylation; Characterization; Viscosity; KONJAC GLUCOMANNAN; PLANT MUCILAGES; POLYSACCHARIDE; CELLULOSE; EXPRESSION; ACYLATION; GELATION;

D O I：

10.1016/j.carbpol.2012.02.065

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Glucomannans from Bletilla striata (bletillan) were used as excipient for controlled deliveries of drugs, genes and tissue engineering. In the present study, a controlled acetylation method was developed to improve water solubility of bletillan 70 (BT) firstly, by reacting with acetic anhydride (AA) in N,N-dimethylformamide solvent. The preparation parameters, such as reaction temperature, reaction time and molar ratio of BT/AA, were optimized based on degrees of acetyl group in addition. IR and H-1 NMR spectra were applied to elucidate the reaction process and substitution pattern, which indicated that the acetylation took place at C-6 and C-2 of the hexose units in a ratio of 2:1, with DS up to 0.83. Relative viscosity analysis revealed that the resulted products had improved water solubilities. This novel method is simple, economic and easily controlled. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：158 / 162

页数：5

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