Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

被引：129
作者：
Fleming, Sheila M. [1 ,2 ]
Ekhator, Osunde R. [1 ,2 ]
Ghisays, Valentins [1 ]
机构：
[1] Univ Cincinnati, Dept Psychol, Cincinnati, OH 45221 USA
[2] Univ Cincinnati, Dept Neurol, Cincinnati, OH 45221 USA
来源：
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2013年 / 76期
关键词：
Behavior; Issue; 76; Neuroscience; Neurobiology; Medicine; Biomedical Engineering; Anatomy; Physiology; Psychology; Basal Ganglia Diseases; Parkinsonian Disorders; Parkinson Disease; Genetics; Behavioral; Psychopharmacology; sensory; motor; mouse; movement disorders; beam; cylinder; animal model; MOTOR DEFICITS; SUBSTANTIA-NIGRA; MICE; DOPAMINE; TRANSPLANTATION; DEGENERATION; ASYMMETRIES; GENE; GDNF;
D O I：
10.3791/50303
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sensitive and reliable behavioral outcome measures are essential to the evaluation of potential therapeutic treatments in preclinical trials for many neurodegenerative diseases. In Parkinson's disease, sensorimotor tests sensitive to varying degrees of nigrostriatal dysfunction are fundamental for testing the efficacy of potential therapeutics. Reliable and quite elegant sensorimotor measures exist for rats, however many of these tests measure sensorimotor asymmetry within the rat and are not entirely suitable for the newer genetic mouse models of PD. We have put together a battery of sensorimotor tests inspired by the sensitive tests in rats and adapted for mice. The test battery highlighted in this study is chosen for a) its sensitivity in a wide variety of mouse models of PD, b) its ease in implementing into a study, and c) its low expense. These tests have proven useful in characterizing novel genetic mouse models of PD as well as in testing potential disease-modifying therapies.
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页数：7
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